CARDARINE

For research purposes only. Not for human or veterinary use.

Cardarine (GW-501516)—a compound often mistaken for a SARM but technically a PPARδ (peroxisome proliferator-activated receptor delta) agonist.

Originally developed in the 1990s by GlaxoSmithKline and Ligand Pharmaceuticals, Cardarine was intended to treat metabolic and cardiovascular diseases, including obesity, diabetes, and dyslipidemia.

 

Chemical & Biological Properties

– IUPAC Name: 2-(4-((2-(4-(Trifluoromethyl)phenyl)thiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid

– CAS Number: 317318-70-0

– Molecular Formula: C₂₁H₁₈F₃NO₃S₂

– Molar Mass: 453.5 g/mol

– Half-Life: Approximately 16–24 hours, allowing for once-daily dosing

– Mechanism: Activates PPARδ, enhancing fatty acid oxidation and glucose metabolism

 

Potential Benefits

– Fat Loss: Promotes lipolysis and shifts the body’s energy use toward fat rather than glucose

– Endurance: Increases aerobic capacity and stamina, making it popular among athletes

– Cholesterol Regulation: Improves HDL (good cholesterol) and reduces LDL (bad cholesterol)

– Insulin Sensitivity: May help regulate blood sugar levels

 

Side Effects & Risks

– Carcinogenic Concerns: Animal studies showed tumor development at high doses, leading to halted clinical trials

– Liver Stress: Potential for elevated liver enzymes

– Headaches, joint pain, and digestive discomfort reported anecdotally

– Long-Term Safety: Not well understood—use carries significant risk

 

Detection Time

– Urine Detection: Cardarine can be detected in urine for up to 40 days after the last dose, though some anecdotal reports suggest it may linger even longer depending on dosage and individual metabolism.

– Blood Detection: Less commonly tested, but metabolites may still be traceable for several weeks.

 

Recommended Cycling Protocols for Cardarine (GW-501516)

– Beginner: 6–8 weeks at 10 mg/day

– Intermediate: 8–10 weeks at 15 mg/day

– Advanced: 10–12 weeks at 20 mg/day

 

Goal-Specific Cycles

Cutting

– Dosage: 10–20 mg/day

– Duration: 8 weeks

– Stacking: Often paired with Ostarine (MK-2866) or Andarine (S4)

– Goal: Maximize fat loss while preserving lean muscle

Endurance & Performance

– Dosage: 10–15 mg/day

– Duration: 6–8 weeks

– Ideal For: Runners, cyclists, and athletes seeking stamina boosts

Recomposition

– Dosage: 15–20 mg/day

– Duration: 8–10 weeks

– Stacking: Commonly combined with LGD-4033 or RAD-140

– Goal: Simultaneous fat loss and muscle gain

 

Post-Cycle Therapy (PCT)

– Required? No. Cardarine does not suppress testosterone, so PCT is not necessary

– Break Between Cycles: Recommended 4–6 weeks off to maintain long-term health and receptor sensitivity

 

 “CARDARINE”

	Per 1 caps.	RMV
CARDARINE (GW 501516)	10 mg.	*